La Genómica y su papel en el desarrollo de la Odontología
DOI:
https://doi.org/10.31984/oactiva.v9i3.1054Palabras clave:
Caries dental, genética, genómica, tecnologías , odontología personalizadaResumen
Esta investigación examina el impacto de las tecnologías 'genómicas' en odontología mediante una revisión bibliográfica en Google Académico, PubMed y Scopus. Se abordaa la genómica identificando avances cronológicos. Se destaca la influencia de estas tecnologías en la exploración, diagnóstico e identificación de marcadores moleculares de enfermedades de la cavidad oral y de interés odontológico, empleando GWAS para comprender la base genómica de la formación dental. Se exploran variantes genéticas en maloclusión, alineación dental y la relación con la respuesta inmune local entre otros. Se identifican marcadores genómicos en regeneración ósea y biomarcadores en saliva. El estudio concluye con la genómica bacteriana en caries y la nueva era en estudios ómicos periodontales, ofreciendo una comprensión completa del impacto de las ómicas en odontología y sus implicaciones para diagnóstico y tratamiento personalizado.
Descargas
Citas
Lay JO, Liyanage R, Borgmann S, Wilkins CL. Problems with the “omics”. TrAC Trends Anal Chem. diciembre de 2006;25(11):1046-56.
Pirih N, Kunej T. Toward a Taxonomy for Multi-Omics Science? Terminology Development for Whole Genome Study Approaches by Omics Technology and Hierarchy. OMICS J Integr Biol. enero de 2017;21(1):1-16.
Dai X, Shen L. Advances and Trends in Omics Technology Development. Front Med. 2022;9:911861.
Manzoni C, Kia DA, Vandrovcova J, Hardy J, Wood NW, Lewis PA, et al. Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences. Brief Bioinform. 1 de marzo de 2018;19(2):286-302.
Chakraborty S, Hosen MI, Ahmed M, Shekhar HU. Onco-Multi-OMICS Approach: A New Frontier in Cancer Research. BioMed Res Int. 2018;2018:9836256.
Araujo J, Castillo M, Wilches Visbal J. Tecnologías emergentes en odontología. Ustasalud. 21 de noviembre de 2023;22:1-2.
Lederberg J, McCray AT. ’Ome Sweet ’Omics-- A Genealogical Treasury of Words.
B K. Beer, Bethesda, and biology: how «genomics» came into being. J Natl Cancer Inst [Internet]. 21 de enero de 1998 [citado 24 de enero de 2024];90(2). Disponible en: https://pubmed.ncbi.nlm.nih.gov/9450566/
Petsko GA. No place like Ome. Genome Biol. 2002;3(7):comment1010.1-comment1010.2.
Butler D. Are you ready for the revolution? Nature. 15 de febrero de 2001;409(6822):758-60.
Schaefer AS, Richter GM, Nothnagel M, Manke T, Dommisch H, Jacobs G, et al. A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis. Hum Mol Genet. 1 de febrero de 2010;19(3):553-62.
Rhodin K, Divaris K, North KE, Barros SP, Moss K, Beck JD, et al. Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses. J Dent Res. septiembre de 2014;93(9):882-90.
Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. diciembre de 1999;4(1):1-6.
Uffelmann E, Huang QQ, Munung NS, de Vries J, Okada Y, Martin AR, et al. Genome-wide association studies. Nat Rev Methods Primer. 26 de agosto de 2021;1(1):1-21.
Fujihara C, Hafiyyah OA, Murakami S. Identification of disease-associate variants of aggressive periodontitis using genome-wide association studies. Jpn Dent Sci Rev. diciembre de 2023;59:357-64.
Johannsdottir B, Thorarinsson F, Thordarson A, Magnusson TE. Heritability of craniofacial characteristics between parents and offspring estimated from lateral cephalograms. Am J Orthod Dentofacial Orthop. 1 de febrero de 2005;127(2):200-7.
Liu F, Lijn F van der, Schurmann C, Zhu G, Chakravarty MM, Hysi PG, et al. A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans. PLOS Genet. 13 de septiembre de 2012;8(9):e1002932.
Savoye I, Loos R, Carels C, Derom C, Vlietinck R. A genetic study of anteroposterior and vertical facial proportions using model-fitting. Angle Orthod. 1 de octubre de 1998;68(5):467-70.
King L, Harris EF, Tolley EA. Heritability of cephalometric and occlusal variables as assessed from siblings with overt malocclusions. Am J Orthod Dentofacial Orthop. 1 de agosto de 1993;104(2):121-31.
Carson EA. Maximum likelihood estimation of human craniometric heritabilities. Am J Phys Anthropol. 2006;131(2):169-80.
von Cramon-Taubadel N. Global human mandibular variation reflects differences in agricultural and hunter-gatherer subsistence strategies. Proc Natl Acad Sci U S A. 6 de diciembre de 2011;108(49):19546-51.
Suri M. Craniofacial syndromes. Semin Fetal Neonatal Med. 1 de junio de 2005;10(3):243-57.
Alotaibi RN, Howe BJ, Moreno Uribe LM, Ramirez CV, Restrepo C, Deleyiannis FWB, et al. Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort. Front Dent Med. 2021;2:771116.
Vieira AR, McHenry TG, Daack-Hirsch S, Murray JC, Marazita ML. A genome wide linkage scan for cleft lip and palate and dental anomalies. Am J Med Genet A. 1 de junio de 2008;146A(11):1406-13.
Cao H, Amendt BA. pySAPC, a python package for sparse affinity propagation clustering: Application to odontogenesis whole genome time series gene-expression data. Biochim Biophys Acta. noviembre de 2016;1860(11 Pt B):2613-8.
Lupo PJ, Mitchell LE, Jenkins MM. Genome‐wide association studies of structural birth defects: A review and commentary. Birth Defects Res. noviembre de 2019;111(18):1329-42.
Zeng Z, Shaffer JR, Wang X, Feingold E, Weeks DE, Lee M, et al. Genome-wide Association Studies of Pit-and-Fissure- and Smooth-surface Caries in Permanent Dentition. J Dent Res. mayo de 2013;92(5):432-7.
Mitchell LE, Agopian AJ, Bhalla A, Glessner JT, Kim CE, Swartz MD, et al. Genome-wide association study of maternal and inherited effects on left-sided cardiac malformations. Hum Mol Genet. 1 de enero de 2015;24(1):265-73.
Geller F, Feenstra B, Zhang H, Shaffer JR, Hansen T, Esserlind AL, et al. Genome-wide association study identifies four loci associated with eruption of permanent teeth. PLoS Genet. septiembre de 2011;7(9):e1002275.
da Fontoura CSG, Miller SF, Wehby GL, Amendt BA, Holton NE, Southard TE, et al. Candidate Gene Analyses of Skeletal Variation in Malocclusion. J Dent Res. julio de 2015;94(7):913-20.
Zebrick B, Teeramongkolgul T, Nicot R, Horton MJ, Raoul G, Ferri J, et al. ACTN3 R577X genotypes associate with Class II and deepbite malocclusions. Am J Orthod Dentofac Orthop Off Publ Am Assoc Orthod Its Const Soc Am Board Orthod. noviembre de 2014;146(5):603-11.
Neela PK, Atteeri A, Mamillapalli PK, Sesham VM, Keesara S, Chandra J, et al. Genetics of Dentofacial and Orthodontic Abnormalities. Glob Med Genet. diciembre de 2020;07(4):95-100.
Soni R, Vivek R, Srivastava A, Singh A, Srivastava S, Chaturvedi TP. Van der Woude Syndrome Associated with Hypodontia: A Rare Clinical Entity. Case Rep Dent. 23 de diciembre de 2012;2012:e283946.
Lone IM, Zohud O, Midlej K, Paddenberg E, Krohn S, Kirschneck C, et al. Anterior Open Bite Malocclusion: From Clinical Treatment Strategies towards the Dissection of the Genetic Bases of the Disease Using Human and Collaborative Cross Mice Cohorts. J Pers Med. 17 de noviembre de 2023;13(11):1617.
Zohud O, Lone IM, Midlej K, Obaida A, Masarwa S, Schröder A, et al. Towards Genetic Dissection of Skeletal Class III Malocclusion: A Review of Genetic Variations Underlying the Phenotype in Humans and Future Directions. J Clin Med. 29 de abril de 2023;12(9):3212.
Hartsfield JK, Jacob GJ, Morford LA. Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped? Semin Orthod. diciembre de 2017;23(4):336-47.
Moreno Uribe LM, Miller SF. Genetics of the dentofacial variation in human malocclusion. Orthod Craniofac Res. abril de 2015;18 Suppl 1(0 1):91-9.
Gershater E, Li C, Ha P, Chung CH, Tanna N, Zou M, et al. Genes and Pathways Associated with Skeletal Sagittal Malocclusions: A Systematic Review. Int J Mol Sci. 2 de diciembre de 2021;22(23):13037.
Zhao Y, Gui L, Hou C, Zhang D, Sun S. GwasWA: A GWAS one-stop analysis platform from WGS data to variant effect assessment. Comput Biol Med. 8 de diciembre de 2023;169:107820.
Croucher PJP, Mascheretti S, Hampe J, Huse K, Frenzel H, Stoll M, et al. Haplotype structure and association to Crohn’s disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet EJHG. enero de 2003;11(1):6-16.
Laine ML, Crielaard W, Loos BG. Genetic susceptibility to periodontitis. Periodontol 2000. febrero de 2012;58(1):37-68.
Ghallab NA. Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: Review of the current evidence. Arch Oral Biol. marzo de 2018;87:115-24.
Lacruz RS, Smith CE, Bringas P, Chen YB, Smith SM, Snead ML, et al. Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. mayo de 2012;227(5):2264-75.
Farrow E, Rengasamy Venugopalan S, Thiffault I, Saunders C. Examination of rare genetic variants in dental enamel genes: The potential role of next-generation sequencing in primary dental care. Orthod Craniofac Res. mayo de 2019;22 Suppl 1:49-55.
Jeremias F, Koruyucu M, Küchler EC, Bayram M, Tuna EB, Deeley K, et al. Genes expressed in dental enamel development are associated with molar-incisor hypomineralization. Arch Oral Biol. octubre de 2013;58(10):1434-42.
Chisini LA, Santos F da C, de Carvalho RV, Horta BL, Tovo-Rodrigues L, Demarco FF, et al. Impact of tooth mineral tissues genes on dental caries: A birth-cohort study. J Dent. junio de 2023;133:104505.
Shaffer JR, Carlson JC, Stanley BOC, Feingold E, Cooper M, Vanyukov MM, et al. Effects of enamel matrix genes on dental caries are moderated by fluoride exposures. Hum Genet. febrero de 2015;134(2):159-67.
Zou T, Foxman B, McNeil DW, Weinberg SM, Marazita ML, Shaffer JR. Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions. Genes. 17 de marzo de 2023;14(3):736.
Vieira AR, Bayram M, Seymen F, Sencak RC, Lippert F, Modesto A. In Vitro Acid-Mediated Initial Dental Enamel Loss Is Associated with Genetic Variants Previously Linked to Caries Experience. Front Physiol. 2017;8:104.
Randazzo AC, Burnheimer JM, Bayram M, Seymen F, Vieira AR. Genetic polymorphisms influence shear bond resistance of orthodontic brackets. J World Fed Orthod. septiembre de 2020;9(3):101-5.
Ajith A, Subbiah U. In silico screening of non-synonymous SNPs in human TUFT1 gene. J Genet Eng Biotechnol. 6 de octubre de 2023;21(1):95.
Vieira AR, Albandar JM. Role of genetic factors in the pathogenesis of aggressive periodontitis. Periodontol 2000. junio de 2014;65(1):92-106.
Shi Q, Luan Q, Wang X, Cai Y. Correlation study on mtDNA polymorphisms as potential risk factors in aggressive periodontitis by NGS. Oral Dis. marzo de 2020;26(2):401-8.
Ebersole JL, Dawson DR, Morford LA, Peyyala R, Miller CS, Gonzaléz OA. Periodontal disease immunology: «double indemnity» in protecting the host. Periodontol 2000. junio de 2013;62(1):163-202.
Borilova Linhartova P, Danek Z, Deissova T, Hromcik F, Lipovy B, Szaraz D, et al. Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis. Int J Mol Sci. 2 de julio de 2020;21(13):4728.
Brett PM, Zygogianni P, Griffiths GS, Tomaz M, Parkar M, D’Aiuto F, et al. Functional gene polymorphisms in aggressive and chronic periodontitis. J Dent Res. diciembre de 2005;84(12):1149-53.
Meng H, Ren X, Tian Y, Feng X, Xu L, Zhang L, et al. Genetic study of families affected with aggressive periodontitis. Periodontol 2000. junio de 2011;56(1):87-101.
Kulkarni C, Kinane DF. Host response in aggressive periodontitis. Periodontol 2000. junio de 2014;65(1):79-91.
Schulz S, Stein JM, Altermann W, Klapproth J, Zimmermann U, Reichert Y, et al. Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis. Hum Immunol. octubre de 2011;72(10):940-6.
Fliefel R, Kühnisch J, Ehrenfeld M, Otto S. Gene Therapy for Bone Defects in Oral and Maxillofacial Surgery: A Systematic Review and Meta-Analysis of Animal Studies. Stem Cells Dev. 15 de febrero de 2017;26(4):215-30.
Steinhardt Y, Aslan H, Regev E, Zilberman Y, Kallai I, Gazit D, et al. Maxillofacial-derived stem cells regenerate critical mandibular bone defect. Tissue Eng Part A. noviembre de 2008;14(11):1763-73.
Matichescu A, Ardelean LC, Rusu LC, Craciun D, Bratu EA, Babucea M, et al. Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration-A Review. Mater Basel Switz. 23 de noviembre de 2020;13(22):5303.
Smeets R, Henningsen A, Zernial O, Stürmer E, Fiedler I, Schäfer S, et al. New and innovative biomaterials, techniques and therapy concepts: Biologization in maxillofacial surgery, oral surgery and dentistry is in full swing. PRF, PRGF, PRP, blood plasma-stabilized augmentations, supplementation of micronutrients and vitamins - what opportunities do such «biological» approaches actually offer? We introduce them here. GMS Interdiscip Plast Reconstr Surg DGPW. 2022;11:Doc05.
Meyer U, Wiesmann HP, Berr K, Kübler NR, Handschel J. Cell-based bone reconstruction therapies-principles of clinical approaches. Int J Oral Maxillofac Implants. 2006;21(6):899-906.
Araújo CRG, Astarita C, D’Aquino R, Pelegrine AA. Evaluation of Bone Regeneration in Rat Calvaria Using Bone Autologous Micrografts and Xenografts: Histological and Histomorphometric Analysis. Mater Basel Switz. 25 de septiembre de 2020;13(19):4284.
Seo JI, Lim JH, Jo WM, Lee JK, Song SI. Effects of rhBMP-2 with various carriers on maxillofacial bone regeneration through computed tomography evaluation. Maxillofac Plast Reconstr Surg. 27 de octubre de 2023;45(1):40.
Kim YK, Lee JY, Kim SG, Lim SC. Guided bone regeneration using demineralized allogenic bone matrix with calcium sulfate: case series. J Adv Prosthodont. mayo de 2013;5(2):167-71.
Jee YJ. Use of platelet-rich fibrin and natural bone regeneration in regenerative surgery. J Korean Assoc Oral Maxillofac Surg. junio de 2019;45(3):121-2.
Varghese MP, Manuel S, Kumar L K S. Potential for Osseous Regeneration of Platelet-Rich Fibrin-A Comparative Study in Mandibular Third Molar Impaction Sockets. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg. julio de 2017;75(7):1322-9.
Divaris K, Monda KL, North KE, Olshan AF, Reynolds LM, Hsueh WC, et al. Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet. 1 de junio de 2013;22(11):2312-24.
Shungin D, Haworth S, Divaris K, Agler CS, Kamatani Y, Keun Lee M, et al. Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. Nat Commun. 24 de junio de 2019;10(1):2773.
Zhu G, Cui X, Fan L, Pan Y, Wang L. Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis. Cells. 23 de diciembre de 2022;12(1):70.
Vaithilingam RD, Safii SH, Baharuddin NA, Ng CC, Cheong SC, Bartold PM, et al. Moving into a new era of periodontal genetic studies: relevance of large case-control samples using severe phenotypes for genome-wide association studies. J Periodontal Res. diciembre de 2014;49(6):683-95.
Schaefer AS, Bochenek G, Jochens A, Ellinghaus D, Dommisch H, Güzeldemir-Akçakanat E, et al. Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Circ Cardiovasc Genet. febrero de 2015;8(1):159-67.
Teumer A, Holtfreter B, Völker U, Petersmann A, Nauck M, Biffar R, et al. Genome-wide association study of chronic periodontitis in a general German population. J Clin Periodontol. noviembre de 2013;40(11):977-85.
Offenbacher S, Divaris K, Barros SP, Moss KL, Marchesan JT, Morelli T, et al. Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. Hum Mol Genet. 15 de mayo de 2016;25(10):2113-29.
Agler CS, Shungin D, Ferreira Zandoná AG, Schmadeke P, Basta PV, Luo J, et al. Protocols, Methods, and Tools for Genome-Wide Association Studies (GWAS) of Dental Traits. Methods Mol Biol Clifton NJ. 2019;1922:493-509.
Kim H, Gordon S, Dionne R. Genome-wide approaches (GWA) in oral and craniofacial diseases research. Oral Dis. marzo de 2013;19(2):111-20.
Duquette D. Implementation of public health genomics and applications to public health dentistry. J Public Health Dent. marzo de 2020;80 Suppl 1:S37-42.
Descargas
Publicado
- Resumen 70
- DESCARGAR EN PDF 31
Cómo citar
Número
Sección
Licencia
Derechos de autor 2024 Odontología Activa Revista Científica

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Se autoriza la reproducción total y parcial, y la citación del material que aparece en la revista, siempre y cuando se indique de manera explícita: nombre de la revista, nombre del autor(es), año, volumen, número y páginas del artículo fuente. Las ideas y afirmaciones consignadas por los autores están bajo su responsabilidad y no interpretan necesariamente las opiniones y políticas del Consejo Editorial de la Revista OActiva ni de la Universidad Católica de Cuenca.
La Revista OActiva utiliza la Licencia Creative Commons de Reconocimeinto-NoComercial-CompartirIgual 4.0, que es la siguiente: CC BY-NC-SA 4.0 Internacional.